ETF comparison
IXJ vs XBI
Both Healthcare.
iShares Global Healthcare ETF · State Street SPDR S&P Biotech ETF
Holdings overlap
8 positions appear in both funds. Buying equal dollars of IXJ and XBI would leave roughly 6.1% of each dollar exposed to the same underlying securities.
Side by side
Sub-score comparison
Tracking quality isn't part of the composite — see what we don't score for why.
Cost difference
XBI is 5 bps cheaper than IXJ. On a $100,000 position that's about $50/yr more in fees for IXJ.
Fee figure is the annual expense charged on $100,000. To see how the gap compounds over a multi-decade holding period, open the cost calculator pre-filled with IXJ vs XBI.
Top shared holdings
8 shared in total| # | Holding | In IXJ | In XBI | Overlap |
|---|---|---|---|---|
| 1 | ABBVIE INC. | 4.98% | 1.09% | 1.09% |
| 2 | GILEAD SCIENCES, INC. | 2.29% | 1.09% | 1.09% |
| 3 | AMGEN INC. | 2.51% | 1.06% | 1.06% |
| 4 | VERTEX PHARMACEUTICALS INCORPORATED | 1.50% | 1.03% | 1.03% |
| 5 | REGENERON PHARMACEUTICALS, INC. | 1.03% | 1.14% | 1.03% |
| 6 | BIOGEN INC. | 0.36% | 1.10% | 0.36% |
| 7 | MODERNA, INC. | 0.23% | 1.03% | 0.23% |
| 8 | INCYTE CORPORATION | 0.21% | 1.13% | 0.21% |
Only in IXJ
105 total- ELI LILLY AND COMPANY 9.44%
- JOHNSON & JOHNSON 7.63%
- ASTRAZENECA PLC 4.02%
- MERCK & CO., INC. 3.96%
- Novartis AG 3.87%
- Roche Holding AG 3.72%
- UNITEDHEALTH GROUP INCORPORATED 3.25%
- THERMO FISHER SCIENTIFIC INCORPORATED 2.45%
- ABBOTT LABORATORIES 2.37%
- INTUITIVE SURGICAL, INC. 2.17%
Only in XBI
146 total- Apellis Pharmaceuticals Inc 1.83%
- Alkermes PLC 1.45%
- Madrigal Pharmaceuticals Inc 1.38%
- TG Therapeutics Inc 1.35%
- Insmed Inc 1.34%
- Scholar Rock Holding Corp 1.30%
- Apogee Therapeutics Inc 1.28%
- Protagonist Therapeutics Inc 1.24%
- Summit Therapeutics Inc 1.24%
- United Therapeutics Corp 1.24%
Open IXJ or XBI at a brokerage
Both funds trade commission-free at major US brokerages.
Affiliate links — opening an account through these earns PlainIndex a one-time referral. Scoring is computed before any affiliate consideration; see our methodology and funding disclosure.
Holdings overlap is the sum of min(weight_a, weight_b) over positions
matched on ISIN (CUSIP fallback). Methodology: see
/methodology/.
Comparing two funds doesn't endorse swapping one for the other. Tax-lot history, account type, and personal goals matter — PlainIndex publishes data and methodology, not investment advice.