ETF comparison
VHT vs XBI
Both Healthcare.
Vanguard Health Care Index Fund ETF Shares · State Street SPDR S&P Biotech ETF
Holdings overlap
133 positions appear in both funds. Buying equal dollars of VHT and XBI would leave roughly 12.7% of each dollar exposed to the same underlying securities.
Side by side
Sub-score comparison
Tracking quality isn't part of the composite — see what we don't score for why.
Cost difference
VHT is 26 bps cheaper than XBI. On a $100,000 position that's about $260/yr more in fees for XBI.
Fee figure is the annual expense charged on $100,000. To see how the gap compounds over a multi-decade holding period, open the cost calculator pre-filled with VHT vs XBI.
Top shared holdings
133 shared in total| # | Holding | In VHT | In XBI | Overlap |
|---|---|---|---|---|
| 1 | Regeneron Pharmaceuticals Inc | 1.21% | 1.14% | 1.14% |
| 2 | AbbVie Inc | 6.08% | 1.09% | 1.09% |
| 3 | Gilead Sciences Inc | 2.74% | 1.09% | 1.09% |
| 4 | Amgen Inc | 3.10% | 1.06% | 1.06% |
| 5 | Vertex Pharmaceuticals Inc | 1.89% | 1.03% | 1.03% |
| 6 | Alnylam Pharmaceuticals Inc | 0.65% | 1.18% | 0.65% |
| 7 | Insmed Inc | 0.47% | 1.34% | 0.47% |
| 8 | Biogen Inc | 0.42% | 1.10% | 0.42% |
| 9 | Natera Inc | 0.40% | 1.16% | 0.40% |
| 10 | United Therapeutics Corp | 0.32% | 1.24% | 0.32% |
| 11 | Incyte Corp | 0.25% | 1.13% | 0.25% |
| 12 | Moderna Inc | 0.24% | 1.03% | 0.24% |
Only in VHT
275 total- Eli Lilly & Co 12.54%
- Johnson & Johnson 8.74%
- Merck & Co Inc 4.58%
- UnitedHealth Group Inc 3.94%
- Abbott Laboratories 3.00%
- Thermo Fisher Scientific Inc 2.92%
- Intuitive Surgical Inc 2.68%
- Pfizer Inc 2.33%
- Danaher Corp 2.01%
- Stryker Corp 1.98%
Only in XBI
21 total- CRISPR Therapeutics AG 1.09%
- Capricor Therapeutics Inc 0.48%
- uniQure NV 0.37%
- Inhibrx Biosciences Inc 0.27%
- SELLAS Life Sciences Group Inc 0.27%
- Compass Therapeutics Inc 0.26%
- Rigel Pharmaceuticals Inc 0.26%
- Sionna Therapeutics Inc 0.22%
- Vor BioPharma Inc 0.22%
- Absci Corp 0.18%
Open VHT or XBI at a brokerage
Both funds trade commission-free at major US brokerages.
Affiliate links — opening an account through these earns PlainIndex a one-time referral. Scoring is computed before any affiliate consideration; see our methodology and funding disclosure.
Holdings overlap is the sum of min(weight_a, weight_b) over positions
matched on ISIN (CUSIP fallback). Methodology: see
/methodology/.
Comparing two funds doesn't endorse swapping one for the other. Tax-lot history, account type, and personal goals matter — PlainIndex publishes data and methodology, not investment advice.